Two nonvolatile liquids were used in the design of liquisolid tablets, tween 80 and propylene glycol. With this technique liquid formulations such as solutions or suspensions of poorly soluble. Liquisolid compact technique for improvementof the. Enhanced dissolution rate of glipizide by a liquisolid technique 1207 both drug and liquid vehicle were mixed and heated to 80900c with constant stirring, the solution was then sonicated for 15 min, until a homogenous drug solution. A liquisolid system refers to formulations formed by conversion of liquid drugs, drug suspensions or drug solution in nonvolatile solvents, into dry, nonadherent, free flowing and compressible powder mixtures by blending the suspension or. Formulation and evaluation of liquisolid compacts for. Use of the liquisolid technique for improvement of the. Liquisolid technique, which is based on the conversion of the drug in liquid state into an apparently dry, nonadherent, free flowing and compressible powder, is a novel and advanced approach to.
Different liquisolid compacts were prepared using a mathematical model to calculate the required quantities of powder and liquid. This technique is suitable for poorly soluble or water insoluble drugs, highly permeable drugs bcs class. A liquisolid system refers to formulations formed by conversion of liquid drugs, drug suspensions or drug solution in nonvolatile solvents, into dry, nonadherent, free flowing and compressible powder mixtures by blending the suspension or solution with selected carriers and coating materials. Liquisolid technique and its applications in pharmaceutics. Self microemulsefying and nonself microemulsefying. The in vitro dissolution property of poorly water soluble nifedipine was improved by exploring the. The liquisolid technique is a novel approach for delivery of drugs. The liquisolid technique as described by spireas is a novel concept, where a liquid may be transformed into a free flowing, readily compressible and apparently dry powder by simple physical blending with selected carrier and coating material. The objective of this article is to present an overview of liquisolid technique and summarize the progress of its applications in phar. Liquisolid technique is a novel approach toward the development of dry, nonadherent, free flowing, and compressible powder from the drug in liquid state.
Research article open access wet granulation to overcome. Pharmaceutical applications of liquisolid technique. The technique of liquisolid compacts is a new and promising addition towards such a novel aim for solubility and dissolution improvement. Liquisolid technique, which is based on the conversion of the drug in liquid state into an apparently dry, nonadherent, free. Orodispersible liquisolid system is the combination of liquisolid technique and orodispersible system. In this study, liquisolid technique was used to formulate glibenclamide into 4 mg dose instead of 5mg. Srinivas vaskula, sateesh kumar vemula, vijaya kumar. Research paper enhanced dissolution rate of glipizide by a. Therefore, the aims of this study are to formulate free flowable and compressible liquisolid powder admixture of glibenclamide using wet granulation technique jointly with liquisolid technique to enhance drug dissolution rate. The poor dissolution rate of water insoluble drug is a major drawback for the development of pharmaceutical dosage forms. Recently, liquisolid technique 10 has shown promising approach for the dissolution enhancement. Several researchers have shown that the liquisolid technique is the most promising method for promoting dissolution rate of poorly watersoluble drugs 35.
Liquisolid technique, which is based on the conversion of the drug in liquid state into an apparently dry, nonadherent, free flowing and compressible powder, is a. By using the liquisolid technique, sustained drug delivery systems were developed. The liquisolid technique is a novel concept, where a liquid may be transformed into a free flowing, readily compressible and apparently dried powder by simple physical blending with selected carrier and coating material. Liquisolid powder system showed acceptable flowability, carrs compressibility index and. Liquisolid technique and its applications in pharmaceutics core. Keywords glibenclamide, liquisolid, liquid load factor, excipient ratio and carrier and coating material.
The increase in the dissolution rate was also found to be significant compared to the marketed product at lower ph values, simulating the gastric environment where valsartan is largely absorbed. Liquisolid technique, which is based on the conversion of the drug in liquid state into an apparently dry, nonadherent, free flowing and compressible powder. Liquisolid technique, flowability, dissolution, liquid load factor. In this technique, the drug is dissolved in a nonvolatile liquid and converted to dry, free. The enhanced rate of indomethacin dissolution from liquisolid tablets was probably due to an increase in wetting properties and surface area of drug particles available for dissolution. Liquisolid technique is novel concept of the drug delivery via the oral route. Liquisolid systems are described as dry, nonadherent, free flowing and compressible powder mixtures acquired by conversion of liquid drugs, drug suspensions or drug solution in nonvolatile solvents with chosen carriers and coating. From this study it concludes that the liquisolid technique is a promising alternative for improvement of dissolution property of waterinsoluble drugs. The liquisolid technique appears to be a promising approach for improving the dissolution of. Angle of repose less than 300 shows the free flowing of the material.
Alpesh yadav 1, isha shah 1, patel chirag j 1, patel harnish k 2, patel priyanka h 3. A mathematical model was utilized to formulate liquisolid tablets. The liquisolid technique is a novel approach for delivery of drugs through the oral route. Liquisolid system and liquimass system are not the same. This technique is a new technique that can approve in industry nowa days new liquisolid technique is populer in world.
This is big achivements of any medicine faculty to form liquisolid tablet. International journal of research in pharmaceutical and nano sciences. Formulation and evaluation of nimodipine tablet by liquisolid. The liquisolid technique as described by spireas is a novel concept, where a liquid may be transformed into a free flowing, readily compressible and apparently dry powder by simple physical blending with selected carrier and coating. The oral absorption of drug is most often controlled by dissolution in the gastrointestinal tract. An approach to enhance the dissolution rate of nimesulide srinivas vaskula, sateesh kumar vemula, vijaya kumar bontha and prasad.
Enhanced dissolution rate of glipizide by a liquisolid technique 1207 both drug and liquid vehicle were mixed and heated to 80900c with constant stirring, the solution was then sonicated for 15 min, until a homogenous drug solution was obtained fahmy and kassem 2008 then, the. Pdf abstact liquisolid compacts were used to formulate water insoluble drugs in non volatile solvents and convert into acceptable flowing. Merits of this approach include low costing, simple processing for the formulation of oily liquid drugs, great potentials in industrial production, possess enhanced in vitro drug release as. Use of the liquisolid compact technique for improvement of. The in vitro release pattern of ls compacts and directly compressed tablets were studied using uspii apparatus. The liquisolid technique systems refers to powdered forms of liquid medications formulated by changing to liquid lipophilic drugs or drug suspensions or solutions of water insoluble solid drugs in suitable nonvolatile solvent systems into drylooking, nonadherent, free moderately flowing. Introduction he liquisolid technique as described by spireas is a novel process, where a liquid may be convert into a free flowing, readily compressible and apparently dry powder by simple blending with. Liquisolid technique as a tool for enhancement of poorly water. The term liquisolid technique refers to immediate release or sustained release tablets or capsules, combined with the inclusion of appropriate adjuvant required for tabletting or encapsulating. The liquisolid technique appears to be a promising approach for improving the dissolution of poorly soluble drugs like valsartan. Sep 09, 2019 pdf abstact liquisolid compacts were used to formulate water insoluble drugs in non volatile solvents and convert into acceptable flowing. This technique was successfully applied to low dose water insoluble drugs. May 30, 2018 orodispersible liquisolid system is the combination of liquisolid technique and orodispersible system.
Formulation and evaluation of nimodipine tablet by. The liquisolid technology is described by spireas as liquid may be transformed into a free flowing, readily compressible, and apparently dry powder by simple physical blending with. Dec 14, 2016 liquisolid technology as described by spireas a liquid may be transformed into a free flowing, readily compressible and apparently dry powder by simple physical blending with selected excipients named the carrier and coating material. Liquisolid powder is a free flowing and a compressible powder form of liquid medication 5. Formulation and evaluation of liquisolid compacts of. Liquisolid technique for enhancement of dissolution properties of carvedilol dinesh m. Design of this technique was according to new mathematical model proposed by spireas et al. The main components of a liquisolid system are a non volatile solvent, carrier and coating materials and a disintegrant. Liquisolid system is an innovative technique used for enhancing dissolution rate and bioavailability of poorly soluble drugs. The in vitro release pattern of liquisolid compacts and directly compressed tablets were studied using uspii apparatus. Improvement of solubility and dissolution of indomethacin by. Pdf liquisolid technique and its applications in pharmaceutics. Javadzadeh y, musaajrezaei, nokhodchi a, liquisolid technique as a new approach to sustain propranolol hydrochloride release from tablet matrices, int j pharm,2008. Mar 17, 2017 s h e f a l i d h a v a d e g u i d e d r.
Spireas and sadu, 1998 concluded that, the new technique of liquisolid compacts appears to be a promising alternative for the formulation of water insoluble drugs such as prednisolone, into rapid release tablets which may. The liquid portion, which can be a liquid drug, a drug suspension or a drug solution in. Several studies have shown that the liquisolid technique is a promising method for promoting dissolution rate of poorly water soluble drugs28. The liquid portion, which can be a liquid drug, a drug suspension or a drug solution in suitable non. The liquid medication is first absorbed into the interior framework of. The liquisolid technique as described by spireas 2002 is a novel concept, where a liquid may be transformed into a free flowing, readily compressible and apparently dry powder by simple physical blending with selected carrier and coating material spireas, 2002. Liquisolid technology as described by spireas a liquid may be transformed into a free flowing, readily compressible and apparently dry powder by simple physical blending with selected excipients named the carrier and coating material. This technique is applied to poorly water soluble, water insoluble or. The in vitro dissolution property of slightly water soluble carvedilol was improved by exploring the potential of liquisolid system ls. In this study nimesulide, a poorly watersoluble, nonsteroidal anti. Liquisolid technique, which is based on the conversion of the drug in liquid state into an apparently dry, nonadherent, free flowing and. Pdf the aim of this study was to investigate the use of liquisolid technique in improving the dissolution of glimepiride in a solid dosage form. Low cost, simple formulation technique and capability of industrial production serve to be the advantages of this technique. However, the formulation of the high dose insoluble drugs as liquisolid tablets is one of the limitations of the liquisolid technique.
The purpose of this study is to develop a novel liquisolid technique to enhance the dissolution rate of poorly water soluble drug carvedilol, a bcs class ii drug, which is a. Depending on the technique used, liquisolid systems may be classified into two categories. B u m r e l a s i n h g a d i n s t i t u t e o f p h a r m a c e u t i c a l s c i e n c e s k u s g a o n b k l o n a v a l a, p u n e 4 1 0 4 0 1 liquisolid technique as a tool for enhancement of dissolution profile of poorly soluble drug. Liquisolid microsystems liquisolid compacts are prepared using the previously outlined method to produce tablets or capsules, whereas the liquisolid microsystems are based on a new concept.
Different ls compacts were prepared using a mathematical model to calculate the required quantities of powder and liquid ingredients to. The new liquisolid technique may be applied to formulate liquid medications i. Javadzadeh y, navimipour b, nokhodchi a, liquisolid technique for dissolution rate enhancement of a high dose water insoluble drug carbamazepine, int j pharm, 2007. Liquisolid technique is a new approach for delivery of drugs through oral route. Liquisolid technique for enhancement of dissolution. Liquisolid technique refers to the conversion of liquid medications into apparently dry, nonadherent, free flowing and compressible powder mixtures by blending the liquid medications with suitable excipients, which are generally termed as carriers and coating materials. The in vitro dissolution property of slightly water soluble fenofibrate fn was improved by exploring the potential of liquisolid system ls. Liquisolid technique is a new and promising method that can change the dissolution rate of water insoluble drugs. In order to investigate the effect of aging on the hardness and dissolution rate of liquisolid compacts, the formulations were stored at 25. International journal of research pharmaceutical and nano. Liquisolid compacts are acceptably free flowing and compressible powder forms of liquid medications. In liquisolid compact, a liquid medication is converted into acceptably flowing and compactible powder forms.
Introduction he liquisolid technique as described by spireas is a novel process, where a liquid may be convert into a free flowing, readily compressible and apparently dry powder by simple blending with selected carrier and coating material. An approach to enhance the dissolution rate of nimesulide srinivas vaskula, sateesh kumar vemula, vijaya kumar bontha and prasad garrepally the present study enlightens to enhance the dissolution rate, absorption efficiency and bioavailability of nimesulide, a poorly solublehighly permeable drug by preparing liquisolid. By using the liquisolid technique, sustained drug delivery systems. Improvement of solubility and dissolution of indomethacin. This technique is suitable for poorly or water insoluble drugs and also for immediate or sustained release formulations.
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